Fault Tolerant Task Mapping in Many-Core Systems

The advent of many-core systems, a network on chip containing hundreds or thousands of homogeneous processors cores, present new challenges in managing the cores effectively in response to processing demands, hardware faults and the need for heat management. Continually diminishing feature size of devices increase the probability of fabrication de- fects and the variability of performance of individual transistors. In many-core systems this can result in the failure of individual processing cores, routing nodes or communication links, which require the use of fault tolerant mechanisms. Diminishing feature size also increases the power density of devices, giving rise to the concept of dark silicon where only a portion of the functionality available on a chip can be active at any one time. Core fault tolerance and management of dark silicon can both be achieved by allocating a percentage of cores to be idle at any one time. Idle cores can be used as dark silicon to evenly distribute heat generated by processing cores and can also be used as spare cores to implement fault tolerance. Both of these can be achieved by the dynamic allocation of processes to tasks in response to changes to the status of hardware resources and the demands placed on the system, which in turn requires real time task mapping. This research proposes the use of a continuous fault/recovery cycle to implement graceful degradation and amelioration to provide real-time fault tolerance. Objective measures for core fault tolerance, link fault tolerance, network power and excess traffic have been developed for use by a multi-objective evolutionary algorithm that uses knowledge of the processing demands and hardware status to identify optimal task mappings. The fault/recovery cycle is shown to be effective in maintaining a high level of performance of a many-core array when presented with a series of hardware faults

XL-STaGe : A Cross-Layer Scalable Tool for Graph Generation, Evaluation and Implementation

This paper presents XL-STaGe, a cross-layer tool for traffic-inclusive directed acyclic graph generation and implementation. In contrast to other graph-generation tools which focus on high-level DAG models, XL-STaGe consists of a set of processes that generate the task-graphs as well as a detailed process model for each node in each graph. The tool is highly customizable, with many parameters that can be tuned to meet the user’s requirements to control the topology, connection density, degree of parallelism and duration the task-graph. Moreover, two use cases are presented, a high-level one, which illustrate the benefit of the developed tool in application mapping and a circuit-level one to verify the accuracy of the XL-STaGe process models when implemented in hardware

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

An automated protocol for assessing career rurality outcomes of Australian health professionals using retrospective data

Introduction: Addressing the imbalance of the health workforce between metropolitan and rural areas requires a clear understanding of trends in choices of work location of health care staff. Objective: Here, we provide an automated and highly reproducible protocol to examine the location of health care workers over multiple years using medical graduates as a case study. Design: Data linkage cohort study. The study cohort examined was University of Wollongong Medical graduates from 2010 to 2021 who were registered to practice in Australia. The main outcome measure was graduate location of practice in Modified Monash regsions MM1 or MM2–7 across multiple postgraduate years. This protocol used R Markdown. Findings: An automated and reproducible protocol was used to analyse choices of work location for the University of Wollongong\u27s medical graduates. Over 90% of graduates were registered with AHPRA. Around 25%–30% of graduates were found to work in MM2–7 regions across their careers, exceeding the national average. Discussion: The protocol presented allows for a fast and reproducible analysis of work location by region for health care workers. This will allow comparisons of outcomes between universities or health professions

UK experience of unrelated cord blood transplantation in paediatric patients

No abstract available

The Burgundy Circle’s plans to undermine Louis XIV’s ‘absolute’ state through polysynody and the high nobility

Louis the duc de Bourgogne (1686 – 1712), grandson of Louis XIV, was briefly Dauphin of France before his premature death from measles. Advised by a group of noted former tutors and members of the court, Bourgogne’s Circle devised a range of plans to reform the French state under his future rule. Opposing the centralising model of sovereignty pursued by Louis XIV, the Circle intended to expand government, decentralise power into the provinces, reform an ailing economy, and resurrect the fortunes of a high-aristocracy believed to have been excluded from meaningful government. The Circle’s conviction that Louis XIV had circumvented the ancient nobility by tyrannical (‘absolutist’) means challenges revisionist interpretations of absolutism in ancien régime France. This article will therefore test revisionist claims that ‘absolutism’ did not exist in France, by assessing the contemporary opinion of the Circle’s key members. In so doing, it will reveal the divergent reform agendas of its members and contest previous historiographical notions that depict the group as possessing a cohesive ideology

The new concrete

The New Concrete is a long-overdue survey of the rise of concrete poetry in the digital age. The accessibility of digital text and image manipulation, modern print techniques and the rise of self-publishing have invigorated a movement that first emerged in an explosion of literary creativity during the 1950s and 1960s. This new volume is a highly illustrated overview of contemporary artists and poets working at the intersection of visual art and literature, producing some of the most engaging and challenging work in either medium. Featuring an introductory essay by renowned American poet Kenneth Goldsmith and edited by celebrated poets Victoria Bean and Chris McCabe, The New Concrete is an indispensable introduction to the breadth of concrete poetry being produced today. Edited by Victoria Bean and Chris McCabe, with an essay by Kenneth Goldsmit

Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients from 29 Countries

Importance: Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events. Objective: To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients. Design, Setting, and Participants: The International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients (INTUBE) study was an international, multicenter, prospective cohort study involving consecutive critically ill patients undergoing tracheal intubation in the intensive care units (ICUs), emergency departments, and wards, from October 1, 2018, to July 31, 2019 (August 28, 2019, was the final follow-up) in a convenience sample of 197 sites from 29 countries across 5 continents. Exposures: Tracheal intubation. Main Outcomes and Measures: The primary outcome was the incidence of major adverse peri-intubation events defined as at least 1 of the following events occurring within 30 minutes from the start of the intubation procedure: cardiovascular instability (either: systolic pressure <65 mm Hg at least once, <90 mm Hg for >30 minutes, new or increase need of vasopressors or fluid bolus >15 mL/kg), severe hypoxemia (peripheral oxygen saturation <80%) or cardiac arrest. The secondary outcomes included intensive care unit mortality. Results: Of 3659 patients screened, 2964 (median age, 63 years; interquartile range [IQR], 49-74 years; 62.6% men) from 197 sites across 5 continents were included. The main reason for intubation was respiratory failure in 52.3% of patients, followed by neurological impairment in 30.5%, and cardiovascular instability in 9.4%. Primary outcome data were available for all patients. Among the study patients, 45.2% experienced at least 1 major adverse peri-intubation event. The predominant event was cardiovascular instability, observed in 42.6% of all patients undergoing emergency intubation, followed by severe hypoxemia (9.3%) and cardiac arrest (3.1%). Overall ICU mortality was 32.8%. Conclusions and Relevance: In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events - in particular cardiovascular instability - were observed frequently